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Millipore EGLP-35K 96T- Glucagon-Like Peptide-1 (Active) ELISA

參考價(jià) 4830
訂貨量 ≥1
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  • 公司名稱 上海浩洋生物科技有限公司
  • 品牌 Millipore/美國(guó)
  • 型號(hào) Millipore EGLP-35K 96T-
  • 產(chǎn)地 Millipore EGLP-35K 96T
  • 廠商性質(zhì) 代理商
  • 更新時(shí)間 2018/10/28 6:26:42
  • 訪問次數(shù) 2485
產(chǎn)品標(biāo)簽

Glucagon-Like Peptide-1 (Active) ELISA

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G418,STZ,DTT,IPTG,MTT,PNPP,X-GLUC,X-GAL,CHAPS,HEPES

Glucagon Like Peptide-1 (Active) ELISA

 
Description:
Glucagon Like Peptide-1 (Active) ELISA
 
Qty/Pk:
96-well plate
 
Background Information:
GLP-1 is secreted from gut endocrine cells in response to nutrient ingestion and plays multiple roles in metabolic homeostasis.
 
Key Applications:
ELISA
 
Application Notes:
Overnight incubation at 4°C, followed by 2 hours 30 minutes at room temperature Sample volume 100 μl serum, plasma or tissue culture medium
 
Species Reactivity:
Mammals
 
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
 
Entrez Gene Summary:
The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.
 
UniProt Summary:
FUNCTION: SwissProt: P01275 # Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.
SIZE: 180 amino acids; 20909 Da
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain.
PTM: Proglucagon is post-translationally processed in a tissue- specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by post-translational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas.
SIMILARITY: SwissProt: P01275 ## Belongs to the glucagon family.
MISCELLANEOUS: In the glucagon antagonist, His-53 and Phe-58 are missing. This antagonist has been successfully utilized to reduce glucose concentration in vivo."
 
Kit or Assay Type:
  • Endocrine Kits
  • ELISA Assays
 
Pack Size:
1
 
Pack Unit:
plates (96 wells)
 
UniProt Number:
P01275
 
Precision, %:
  • Inter-assay: 8 ± 4.8
  • Intra-assay: 7.4 ± 1.1
 
Accuracy:
86.9 ± 5.2%
 
Detection Methods:
  • Fluorescent
  • Fluorescent
 
Gene Symbol:
  • GCG
  • GRPP
  • GLP1
  • GLP2
  • glucagon
 
Cross Reactivity:
GLP-1 is conserved in almost all mammals. This kit may be used to mearure in such species (e.g. rat, mouse, primates, etc.)
 
Product Name:
Glucagon Like Peptide-1 (Active) ELISA
 
Standard Curve Range:
2–100 pM
 
Entrez Gene Number:
NM_002054.2
 
Analytes Available:
Glucagon Like Peptide-1
 
Ordering Description:
Glucagon Like Peptide-1 (Active) ELISA, 96-well plate

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EGLP-35K Glucagon-Like Peptide-1 (Active) ELISA Kit Millipore EA 4830 詳細(xì)查看 訂購(gòu)



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