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【產品簡介】
【詳細說明】
Tertiapin-Q
Blocker of Kir Channels（鉀通道Kir阻斷劑）
Tertiapin has been isolated from the venom of the Honeybee Apis mellifera. Tertiapin-Q is an oxidation-resistant mutant of the wild-type tertiapin where Methionine 13 has been replaced by a Glutamine. Tertiapin-Q blocks the inwardly rectifying Kir1.1 (ROMK1) and Kir3.1/3.4 (GIRK1/GIRK4 also known as IKACh) potassium channels with Kd values of around 2 nM and 8 nM respectively.Tertiapin-Q also inhibits calcium-activated large conductance BK potassium channels (KCa1.1) in a concentration and voltage-dependent manner (IC50 ~ 5 nM), in addition to inhibiting Kir3.1/3.2 (GIRK1/GIRK2) heteromultimer potassium channels with a Kd close to 270 nM. Tertiapin-Q can prevent dose-dependent acetylcholine(ACh)-induced atrioventricular blocks in mammalian hearts, as KCNJ3/KCNJ5 channels (also named I(KACh)), are activated by ACh found in mammalian myocytes.
Tertiapin-Q 技術資料
氨基酸序列：
Ala-Leu-Cys3-Asn-Cys5-Asn-Arg-Ile-Ile-Ile-Pro-His-Gln-Cys14-Trp-Lys-Lys-Cys18-Gly-Lys-Lys-NH2
二硫鍵： Cys3-Cys14 and Cys5-Cys18
長度 (aa)：21
分子式： C106H175N35O24S4
分子量： 2452 Da
外觀：White lyophilized solid
可溶性： water and saline buffer
CAS 號： [252198-49-5]
來源： Synthetic
純度： > 97 %
產品信息
08TER001-00100 | Tertiapin Q | 0.1mg |
08TER001-00500 | Tertiapin Q | 0.5mg |
08TER001-01000 | Tertiapin Q | 1mg |