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【產品簡介】
【詳細說明】
BeKm-1
Selective blocker of ERG1 channel(鉀通道ERG1選擇性阻斷劑)
BeKm-1 toxin is a peptide toxin that has been isolated from the venom of the Central Asian scorpion Buthus eupeus.BeKm-1 toxin has been reported to be a highly selective inhibitor of the human ether-a-go-go ERG1 channel (hERG1) . BeKm-1 inhibits hERG1 channels expressed in HEK-293 cells with an IC50 of 3.3 nM, but has no effect at 100 nM on human EAG, human SK1, rat SK2, human IK, human BK, KCNQ1/KCNE1, KCNQ2/KCNQ3, and KCNQ4 channels. It has also minimal effects on rat ELK1 channel. BeKm-1 inhibits the human ERG1 + KCNE1 combination transiently expressed in HEK-293 cells with an IC50 value in the range of 10 to 30 nM. BeKm-1 toxin preferentially blocks human ERG channel through the closed (resting) state, although some open channel blockade is also reported to occur.
BeKm-1 技術資料
氨基酸序列：
Arg-Pro-Thr-Asp-Ile-Lys-Cys7-Ser-Glu-Ser-Tyr-Gln-Cys13-Phe-Pro-Val-Cys17-Lys-Ser-Arg-Phe-Gly-Lys-Thr-Asn-Gly-Arg-Cys28-Val-Asn-Gly-Phe-Cys33-Asp-Cys35-Phe-OH
二硫鍵：Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35
長度 (aa)： 36
分子式： C174H261N51O52S6
分子量：4091.70 Da
外觀： White lyophilized solid
可溶性：water and saline buffer
CAS 號：Not available
來源： Synthetic
純度： > 97%
產品信息
13BEK001-00100 | BeKm-1 | 0.1mg |
13BEK001-00500 | BeKm-1 | 0.5mg |