NMB-1

NMB-1 (Noxious mechanosensation blocker 1) is an analogue of a peptide isolated from a marine conesnail. This 19 amino acid peptide has shown a 30 fold selectivity in inhibiting slowly adapting mechanically activated currents over rapidly adapting ones. It is an interesting tool to distinguish between RA and SA currents. significantly blocks SA currents at 1 µM in sensory neurons contrary to GsMTx4. Some results suggest that could also block mechanosensitive ion channels in cochlear hair cells at 5 µM.
Smartox Biotechnology is pleased to be the first company offering this research tool.

技術(shù)資料

氨基酸序列：

Phe-Asn-Trp-Arg-Cys-Cys-Leu-Ile-Pro-Cys-Arg-Arg-Asn-His-Lys-Lys-Phe-Phe-Cys-NH₂

二硫鍵：Cys⁵-Cys¹⁹ and Cys⁶-Cys¹⁰ 

長(zhǎng)度 (aa)： 19

分子式： C₁₁₁H₁₆₄N₃₆O₂₁S₄

分子量： 2467.03 Da

外觀：White lyophilized solid

可溶性： aqueous buffer

CAS 號(hào)：not available 

來源：Synthetic

純度：> 95 %

產(chǎn)品信息

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