Recombinant Human sFRP-1,重組人sFRP-1

Recombinant Human sFRP-1

產品編號:

120-29

別名:

Soluble Frizzled Related Protein-1,Secreted Apoptosis Related Protein-2,SARP-2

描述:

Secreted Frizzled Related Proteins （sFRPs） modulate WNT signaling by binding directly to WNT proteins in a manner that affects their receptor binding and signaling capabilities. sFRP-1 is a widely distributed protein that can bind directly to WNT1, WNT2, and possibly other WNT proteins, and generally exerts anti-proliferative effects consistent with activity as a WNT antagonist. It also inhibits apoptosis and has been found to be down-regulated in many solid tumors, but up-regulated in uterine leiomyomas. Recombinant human sFRP-1 is a glycosylated 283 amino acid protein containing a cysteine rich Frizzled homologous domain.

氨基酸序列:

SEYDYVSFQS DIGPYQSGRF YTKPPQCVDI PADLRLCHNV GYKKMVLPNL LEHETMAEVK ASSWVPLL NKNCHAGTQV FLCSLFAPVC LDRPIYPCRW LCEAVRDSCE PVMQFFGFYW PEMLKCDKFP EGDVCIAMTP PNATEASKPQ GTTVCPPCDN ELKSEAIIEH LCASEFALRM KIKEVKKENG DKKIVPKKKK PLKLGPIKKK DLKKLVLYLK NGADCPCHQL DNLSHHFLIM GRKVKSQYLL TAIHKWDKKN KEFKNFMKKM KNHECPTFQS VFK

來源:

HeLa cells

純度:

Greater than 97% by SDS-PAGE gel and HPLC analyses.

生物活性:

Determined by its ability to inhibit BMP-2 proliferation effect of ATDC-5 cells. The expected ED₅₀ is 0.3–0.5 μg/ml.