 |
上海源葉生物科技有限公司
主營產品： S30260異硫氰酸胍,30259鹽酸胍,嗜熱菌蛋白酶 |
15
聯(lián)系電話
15921386130
公司信息
- 聯(lián)系人：
- 何小姐
- 電話：
- 86-021-61559134
- 手機：
- 15921386130
- 傳真：
- 86-021-55068248
- 地址：
- 上海市松江區(qū)長塔路465號6幢
- 郵編：
- 200433
- 網(wǎng)址：
- www.shyuanye.com
S80016
| 參考價 | 面議 |
具體成交價以合同協(xié)議為準
- 型號
- 品牌
- 廠商性質 生產商
- 所在地
更新時間：2025-05-15 18:59:58瀏覽次數(shù)：232
聯(lián)系我們時請說明是化工儀器網(wǎng)上看到的信息，謝謝!
- 提示：詳情請下載說明書。
- 產品描述： b-AP15 is a specific inhibitor of the deubiquitinating enzymes UCHL5 and Usp14.
- 靶點： UCHL5/Usp14
- 體內研究： b-AP15 (2.5 mg/kg) inhibits tumor growth in syngenic mice models with less frequent administration schedules. We administered b-AP15 to C57BL/6J mice with Lewis lung carcinomas (LLCs) using a 2-d-on, 2-d-off schedule and to BALB/c mice with orthotopic breast carcinoma (4T1) using a 1-d-on, 3-d-off schedule. b-AP15 significantly inhibited tumor growth in both models, with T/C=0.16 (P≤0.01) for the C57BL/6J mice and T/C=0.25 (P≤0.001) for the BALB/c mice. A reduction in the number of pulmonary metastases also is observed in the group of mice with 4T1 breast carcinomas treated with b-AP15
- 參考文獻：
1. D'Arcy P, et al. Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nat Med. 2011 Nov 6;17(12):1636-40. 2. Wang X, et al. The 19S Deubiquitinase Inhibitor b-AP15 is Enriched in Cells and Elicits Rapid Commitment to Cell Death. Mol Pharmacol. 2014 Jun;85(6):932-45. 3. Tian Z, et al. A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance. Blood. 2014 Jan 30;123(5):706-16.
- 溶解度： DMSO : 20 mg/mL (47.69 mM; Need ultrasonic)
- 保存條件： 2-8℃
- 配置溶液濃度參考：
1mg 5mg 10mg 1 mM 2.384 ml 11.922 ml 23.844 ml 5 mM 0.477 ml 2.384 ml 4.769 ml 10 mM 0.238 ml 1.192 ml 2.384 ml 50 mM 0.048 ml 0.238 ml 0.477 ml
- 注意：部分產品我司僅能提供部分信息，我司不保證所提供信息的性，僅供客戶參考交流研究之用。
