BD Pharmingen™ APC-Cy™7 Rat Anti-Mouse CD45 561037

克隆:30-F11

尺寸:25 µg

狀態(tài):RUO

品類(lèi)編號(hào):561037

熒光素標(biāo)記APC-Cy7

抗原名稱(chēng)CD45

宿主Rat LOU, also known as Louvain, LOU/C, LOU/M IgG2b, κ

免疫原Mouse Thymus / Spleen

別名Ptprc; LCA; Leukocyte common antigen; T200; Ly-5; Lyt-4

BD Pharmingen™ APC-Cy™7 Rat Anti-Mouse CD45 561037

抗體詳情

30-F11

The 30-F11 clone has been reported to react with all isoforms and both alloantigens of CD45, which is found on hematopoietic stem cells and all cells of hematopoietic origin, except erythrocytes. CD45 is a transmembrane glycoprotein which is expressed at high levels on the cell surface, and its presence distinguishes leukocytes from non-hematopoietic cells. CD45 is a member of the Protein Tyrosine Phosphatase (PTP) family, where the intracellular carboxy-terminal region contains two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of exons 4, 5, and 6 (designated as A, B, and C, respectively).  CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction and the CD45 isoforms detected in the mouse are cell type-, maturation-, and activation state-specific.