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EpiCypher是一家為表觀遺傳學和染色質(zhì)生物學研究提供高質(zhì)量試劑和工具的專業(yè)制造商。EpiCypher能提供全長重組人SMARCA2重塑酶。SMARCA2是ATP依賴性染色質(zhì)重塑復合物SWI/SNF的核心ATP酶亞基，可動員核小體，在基因轉(zhuǎn)錄調(diào)控、發(fā)育、基因組復制和修復中發(fā)揮關(guān)鍵作用[1,2]。SWI/SNF亞基的異常活性與超過20%的人類癌癥和多種發(fā)育障礙相關(guān)，這使得SMARCA2成為一個新興的候選治療靶點[3,4]。SMARCA2可用于結(jié)合EpiDyne®-FRET Remodeling Assay Substrate (EpiCypher 16-4201)在HTS兼容藥物發(fā)現(xiàn)研究。
[1] Clapier & Carins Annu. Rev. Biochem. (2009). PMID: 19355820
[2] Sundaramoorthy & Owen-Hughes F1000Research (2020). PMID: 32864100
[3] Kadoch & Crabtree Sci. Adv. (2015). PMID: 26601204
[4] Cenik & Shilatifard Nat. Rev (2021). PMID: 32958894
產(chǎn)品詳情
宿主來源: Human
表達系統(tǒng): SF9 cells
保存溫度: Stable for six months at -80°C from date of receipt. For best results, aliquot and avoid freeze/thaws.
運輸溫度: Dry ice.
產(chǎn)品形式: SMARCA2 at 0.175 mg/mL in 20.7 µL of 25 mM HEPES pH 7.6, 0.1 mM EDTA, 10% glycerol, 350 mM NaCl, 1 mM DTT, 0.4 mM PMSF, 1 mM benzamidine, 0.02% NP-40, 0.4 mg/mL insulin
驗證數(shù)據(jù)
 | Figure 1: ATP-dependent chromatin remodeling assay EpiDyne®-FRET Chromatin Remodeling Substrate (EpiCypher 16-4201; 20 nM) incubated with SMARCA2 Remodeling Enzyme (concentrations indicated) in 1x SMARCA Remodeling Assay Buffer. Curves denote FRET efficiency/chromatin remodeling. |
 | Figure 2: Protein gel data SMARCA2 Remodeling Enzyme (1 µg) was run on an SDS-PAGE gel and stained with Coomassie blue. The migration and molecular weight of the protein standards are indicated. |
訂購詳情
貨號 | 產(chǎn)品名稱 | 規(guī)格 |
15-1015 | SMARCA2 Chromatin Remodeling Enzyme (Human BRM)/欣博盛生物 | 100 Reactions |
如需了解更多詳細信息或相關(guān)產(chǎn)品，請聯(lián)系EpiCypher中國授權(quán)代理商-欣博盛生物
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