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概述

描述

 Recombinant human LAG3 protein aa 1-450 was produced in mammalian cells with C-terminal His-DYK tag. The theoretical molecular weight of recombinant LAG3 is 47.7 kDa. Purified LAG3 protein is near the position of 55 kDa on SDS-PAGE gel under reduced condition.

LAG3 protein is purified by proprietary chromatographic techniques.

Entrez Gene summary for LAG3:

Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.

UniProtKB/Swiss-Prot: P18627 (LAG3_HUMAN)

Function: Involved in lymphocyte activation. Binds to HLA class-II antigens. 

別名 Lymphocyte activation gene 3 protein
形態 Protein is supplied in 20 mM Tris,150 mM NaCl, 10% Glycerol, pH 7.5
Accession # NP_002277.4

性能
保存方法 Clear solution, frozen.Store at -70°C. At first use, aliquot and store at -70°C to avoid multiple freeze-thaws.
序列 LAG3-His-DYK (N-terminal 28 aa is predicted to be signal peptide): MWEAQFLGLLFLQPLWVAPVKPLQPGAEVPVVWAQEGAPAQLPCSPTIPLQDLSLLRRAGVTWQHQPDSGPPAAAPGHPLAPGPHPAAPSSWGPRPRRYTVLSVGPGGLRSGRLPLQPRVQLDERGRQRGDFSLWLRPARRADAGEYRAAVHLRDRALSCRLRLRLGQASMTASPPGSLRASDWVILNCSFSRPDRPASVHWFRNRGQGRVPVRESPHHHLAESFLFLPQVSPMDSGPWGCILTYRDGFNVSIMYNLTVLGLEPPTPLTVYAGAGSRVGLPCRLPAGVGTRSFLTAKWTPPGGGPDLLVTGDNGDFTLRLEDVSQAQAGTYTCHIHLQELNATVTLAIITVTPKSFGSPGSLGKLLCEVTPVSGQERFVWSSLDTPSQRSFSGPWLEAQEAQLLSQPWQCQLYQGERLLGAAVYFSSPGAQRSGRAPGALPAGHLHHHHHHHHDYKDDDDK