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BPS Bioscience Inc.
中級會員 | 第3年

13829799985

當前位置:BPS Bioscience Inc.>>CAR T-Cell Therapy Cell Lines>> 78557TCR/B2M Knockout NFAT Luciferase Reporter Jurkat Cell Line

TCR/B2M Knockout NFAT Luciferase Reporter Jurkat Cell Line

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產品型號78557

品       牌BPS Bioscience

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更新時間:2024-11-26 15:50:44瀏覽次數:174次

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●Purchase●DescriptionThiscelllineisadoubleknockoutofTCR(TCellReceptor)andB2M(Beta-2-Microglobulin)
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Description

This cell line is a double knockout of TCR (T Cell Receptor) and B2M (Beta-2-Microglobulin). First, the TRAC (T-Cell Receptor Alpha Constant) and the TRBC1 (T-Cell Receptor Beta Constant 1) domains of the TCRα/β chains were genetically removed by CRISPR/Cas9 genome editing from NFAT Luciferase Reporter Jurkat cells to generate the TCR Knockout NFAT Luciferase Reporter Jurkat cell Line (BPS Bioscience #78556). These TCR knockout cells were used to generate a new cell line in which B2M was also genetically removed by CRISPR/Cas9 genome editing.

Expression of the firefly luciferase gene is driven by NFAT response elements located upstream of the minimal TATA promoter. Activation of the NFAT signaling pathway in these cells can be monitored by measuring luciferase activity.

Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.

Synonyms
Beta-2-microglobulin, B2M, CDABP0092, HDCMA22P

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