MG132是一種蛋白酶體抑制劑，抑制蛋白的降解，保存在-20度，避光.
A potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-κB activation (IC50 = 3 µM). Prevents β-secretase cleavage. A 10 mM (1 mg/210 µl) solution of MG-132 (Cat. No. 474791) in DMSO is also available. 
Product information  
Peptide Sequence  Z-Leu-Leu-Leu-CHO  
Form  White solid  
Primary Target  proteasome  
Primary Target Ki  4 nM  
Secondary target  NF-κB (IC50 = 3 µM)  
Molar mass  475.6  
Cell permeable  Yes  
Reversible  Yes  
Purity  ≥98% by HPLC  
Solubility  DMSO or EtOH  
Chemical formula  C26H41N3O5  
CAS number  133407-82-6