The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also designated stromelysin-1, -2 and -3 respectively) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.

基質(zhì)金屬蛋白酶（MMP）是一個(gè)家庭的肽酶的酶降解細(xì)胞外基質(zhì)成分，包括膠原，明膠，纖連蛋白，層粘連蛋白和蛋白多糖。基質(zhì)金屬蛋白酶基因的轉(zhuǎn)錄是由佛波酯激活的差異，脂多糖（LPS）或金黃色葡萄球菌腸毒素B（SEB）。MMP催化需要鈣和鋅。MMP-3，MMP-10和MMP-11（也-1，2和3分別）激活原膠原酶。對(duì)原膠原酶MMP-3可以通過兩種途徑的激活。通過直接激活MMP-3與組織或血漿蛋白酶結(jié)合MMP-3緩慢和激活快速。MMP-10在小腸中的表達(dá)，在肺和心臟水平較低。MMP-11在乳腺癌間質(zhì)細(xì)胞中特異性表達(dá)于上皮細(xì)胞惡性腫瘤。