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英文名稱  Anti-CR1/CD35 
中文名稱   
別    名  Complement receptor type 1; CR1; C3BR; C4BR; CD35; KN; C3-binding protein; CD35 antigen; complement component receptor 1; C3b/C4b receptor; Knops blood group antigen. 
濃    度  1mg/1ml 
規(guī) 格  0.1ml/100μg  0.2ml/200μg 
抗體來源  Rabbit  
克隆類型  polyclonal 
交叉反應  Human   
產品類型  一抗    
研究領域  免疫學 細胞膜受體 淋巴細胞 t-淋巴細胞 b-淋巴細胞  
蛋白分子量  predicted molecular weight: 274kDa 
性    狀  Lyophilized or Liquid 
免 疫 原  KLH conjugated synthetic peptide derived from human CR1 C-terminus 
亞    型  IgG 
純化方法  affinity purified by Protein A 
儲 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Soium zde 
公司的理念是：為您提供抗體及相關標記抗體性價比產品和*的服務。公司能夠及時解決和滿足客戶的各方面的需求，與國內多家企業(yè)建立了良好的*合作關系，在市場上樹立了公司的良好信譽和形象。本公司是專業(yè)經營免疫組化試劑盒，Elisa試劑盒，抗體，抗原，標記抗體，標記抗原，生化試劑的公司，在廣大用戶的幫助和支持下，經過不懈的努力，已成為國內生命科學領域產品的主要供應商之一，代理許多*水平的高科技產品，包括分子生物學、細胞生物學、免疫學、診斷等多個研究及應用領域。公司的服務和業(yè)務網絡遍及全國，在同行獲得*好評。
產品應用   ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:100-500  ICC=1:100-500  IF=1:100-500 
（石蠟切片需做抗原修復） 
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user.  
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
產品介紹 This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized.
Function : Mediates cellular binding of particles and immune complexes that have activated complement.
Subunit : Monomer.
Subcellular Location : Membrane; Single-pass type I membrane protein.
Tissue Specificity : Present on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells.
Similarity : Belongs to the receptors of complement activation (RCA) family.
Contains 30 Sushi (CCP/SCR) domains.
CD35廣泛分布于紅細胞、粒細胞、單核細胞、肥大細胞、濾泡樹突狀細胞、腎小球足突細胞、B細胞及部分CD4+T細胞表面.CD35抗原又稱為CR1或者C3b/C4b R，是一種分子量160-250kDa的C3b/C4b補體結合跨膜蛋白，主要用于濾泡樹突狀細胞標記和濾泡樹突狀細胞瘤的診斷。 
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