核仁蛋白C23抗體Anti-Nucleolin/C23的產(chǎn)品說明（為您現(xiàn)貨供應(yīng)，詳詢）：
--產(chǎn)品介紹：Nucleolin is the major nucleolar protein of growing eukaryotic cells. C23 （nucleolin, NCL） is a eukaryotic nucleolar phosphoprotein that influences synthesis and maturation of ribosomes. C23 localizes to dense fibrillar regions of the nucleolus. It contains four RNA binding domains that interact with pre-rRNA during synthesis. C23 can influence RNA processing, ribosomal gene transcription and nucleolar targeting of ribosomal components. It is known to associate with a variety of proteins, including the nucleolar protein B23. Phosphorylation by Cdc2 and casein kinase II causes translocation of C23 from the nucleolus to the cytoplasm. Mitotic phosphorylated forms of Bcl-2 are present in nuclear structures in prophase Hela cells together with C23 and Ki-67. Retinoic acid-induced apoptosis leads to C23 down-regulation and Bcl-2 mRNA instability. C23 binds the human omerase reverse transcriptase subunit （TERT） through interactions with its RNA binding domain 4 and carboxyl-terminal RGG domain, and this interaction is critical for the nucleolar localization of human TERT.Subcellular Location : Nucleus
--該抗體來源于：（Rabbit）
--核仁蛋白C23抗體的參數(shù)介紹：
1、濃度：1mg/1ml
2、交叉反應(yīng)：hu, mo, rat
3、產(chǎn)品類型：一抗
4、研究領(lǐng)域：細(xì)胞生物染色質(zhì)和核信號表觀遺傳學(xué)
5、蛋白分子量：predicted molecular weight: 76kDa
6、性狀：Lyophilized or Liquid
7、免疫原：KLH conjugated synthetic peptide derived from hu Nucleolin/C23
8、亞型：polyclonal
9、純化方法：affinity purified by Protein A
10、儲存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
11、產(chǎn)品應(yīng)用：WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-F=1:100-500IF=1:50-200 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
12、保存條件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

（1mg/1ml核仁蛋白C23抗體Anti-Nucleolin/C23，的相關(guān)產(chǎn)品：免疫組化常用試劑免疫印跡常用試劑各種標(biāo)記二抗）

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